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Lactational exposure to cadmium induced alterations in the hematological indices and the oxidative status in brain, liver and testes of rat pups

Eman E Elsharkawy, Neveen A .El-Nisr.

Cited by (1)

Abstract
Hematology, antioxidant, and certain biochemical indices in brain, liver, and testicular tissues of rat off-springs were studied after lactational cadmium exposure. Lactating SpragueDawley females received either 0 ppb (control) or 20 ppm cadmium chloride in their drinking water during the lactational period. On day 24, the pups were weaned and sacrificed. Distortion of hemopoietic features such as decrease in red blood cells count, hemoglobin, hematocrit, and platelet values were seen in the exposed pups. Increased lipid peroxidation and depressed antioxidant defense levels in brain, liver and testes of the exposed rat pups were observed. Serum activities of alkaline phosphatase and lactate dehydrogenase showed a significant increase, whereas a reduction was observed in the level of testosterone hormone in exposed pups. Cadmium induced neuronal degeneration, necrosis in hepatocytes, and degeneration in seminiferous tubules. These findings indicated that lactational exposure to cadmium can disrupt several organ functions in newborn rat pups.

Key words: Lactational cadmium; Platelets; Antioxidant system, Lactate dehydrogenase; Testosterone; Cerebral cortex.


 
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This Article Cited By the following articles

Protective role of zinc against the neurotoxicity induced by exposure to cadmium during gestation and lactation periods on hippocampal volume of pups tested in early adulthood
Drug and Chemical Toxicology 2018; (): 1.

1
 
How to Cite this Article
Pubmed Style

Eman E Elsharkawy, Neveen A .El-Nisr. Lactational exposure to cadmium induced alterations in the hematological indices and the oxidative status in brain, liver and testes of rat pups. J Environ Occup Health. 2012; 1(3): 147-154. doi:10.5455/jeos.20121010073537


Web Style

Eman E Elsharkawy, Neveen A .El-Nisr. Lactational exposure to cadmium induced alterations in the hematological indices and the oxidative status in brain, liver and testes of rat pups. http://www.jenvoh.com/?mno=24420 [Access: January 28, 2020]. doi:10.5455/jeos.20121010073537


AMA (American Medical Association) Style

Eman E Elsharkawy, Neveen A .El-Nisr. Lactational exposure to cadmium induced alterations in the hematological indices and the oxidative status in brain, liver and testes of rat pups. J Environ Occup Health. 2012; 1(3): 147-154. doi:10.5455/jeos.20121010073537



Vancouver/ICMJE Style

Eman E Elsharkawy, Neveen A .El-Nisr. Lactational exposure to cadmium induced alterations in the hematological indices and the oxidative status in brain, liver and testes of rat pups. J Environ Occup Health. (2012), [cited January 28, 2020]; 1(3): 147-154. doi:10.5455/jeos.20121010073537



Harvard Style

Eman E Elsharkawy, Neveen A .El-Nisr (2012) Lactational exposure to cadmium induced alterations in the hematological indices and the oxidative status in brain, liver and testes of rat pups. J Environ Occup Health, 1 (3), 147-154. doi:10.5455/jeos.20121010073537



Turabian Style

Eman E Elsharkawy, Neveen A .El-Nisr. 2012. Lactational exposure to cadmium induced alterations in the hematological indices and the oxidative status in brain, liver and testes of rat pups. Journal of Environmental and Occupational Health, 1 (3), 147-154. doi:10.5455/jeos.20121010073537



Chicago Style

Eman E Elsharkawy, Neveen A .El-Nisr. "Lactational exposure to cadmium induced alterations in the hematological indices and the oxidative status in brain, liver and testes of rat pups." Journal of Environmental and Occupational Health 1 (2012), 147-154. doi:10.5455/jeos.20121010073537



MLA (The Modern Language Association) Style

Eman E Elsharkawy, Neveen A .El-Nisr. "Lactational exposure to cadmium induced alterations in the hematological indices and the oxidative status in brain, liver and testes of rat pups." Journal of Environmental and Occupational Health 1.3 (2012), 147-154. Print. doi:10.5455/jeos.20121010073537



APA (American Psychological Association) Style

Eman E Elsharkawy, Neveen A .El-Nisr (2012) Lactational exposure to cadmium induced alterations in the hematological indices and the oxidative status in brain, liver and testes of rat pups. Journal of Environmental and Occupational Health, 1 (3), 147-154. doi:10.5455/jeos.20121010073537





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